Product Details
Company Profile

China Manufacturer Sales Highest Quality GAMMA-CYCLODEXTRIN CAS 17465-86-0 For stock delivery

Cyclooctaose Basic information

Product Name:	Cyclooctaose
Synonyms:	CYCLOFLO(TM) 42;CYCLOOCTAOSE;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;GAMMA-CYCLODEXTRIN;SCHARDINGER GAMMA-DEXTRIN;cyclooctaose;gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis
CAS:	17465-86-0
MF:	C48H80O40
MW:	1297.12
EINECS:	241-482-4
Product Categories:	Alcohols;Building Blocks;C11 to C30+;C20 to C60+;Chemical Synthesis;rs;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Organic Building Blocks;Oxygen Compounds;Dextrins,Sugar & Carbohydrates
Mol File:	17465-86-0.mol

Cyclooctaose Chemical Properties

Melting point	≥300 °C
alpha	[α]D25 +174～+179° (c=1, H2O) (After Drying)
Boiling point	845.2°C (rough estimate)
density	1.2064 (rough estimate)
refractive index	1.7500 (estimate)
Fp	450℃
solubility	1 M NaOH: 25 mg/mL, may be clear to slightly hazy
pka	11.68±0.70(Predicted)
form	powder
color	white
optical activity	[α]/D 174.0 to 180.0°
Water Solubility	232g/L(25 ºC)
λmax	λ: 420 nm Amax: ≤0.20
Merck	14,2718
BRN	5725162
InChIKey	GDSRMADSINPKSL-HSEONFRVSA-N
EPA Substance Registry System	.gamma.-Cyclodextrin (17465-86-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
WGK Germany	2
RTECS	GU2293080
F	3
HS Code	29400000

MSDS Information

Provider	Language
gamma-Cyclodextrin	English
SigmaAldrich	English

Cyclooctaose Usage And Synthesis

Chemical Properties	White powder or crystal
Chemical Properties	Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.
Production Methods	Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
Pharmaceutical Applications	Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex. Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability. Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility. In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent. In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as cortico. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation. Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.
Safety	Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations. Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity. Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries. Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic. γ-Cyclodextrin LD50 (rat, IP): 4.6 g/kg LD50 (rat ,IV): 4.0 g/kg LD50 (rat, oral): 8.0 g/kg
storage	Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.
Regulatory Status	Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections). Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Cyclooctaose Preparation Products And Raw materials

Raw materials

D(+)-Glucose-->Dextrin-->BETA-CYCLODEXTRIN-->Superoxide dismutase-->Decane-->Cyclohexaose-->MALTOOCTAOSE

Product Tags:

benzylamine hcl supplier

tetrasodium edta suppliers suppliers

methyl methacrylate supplier

China Manufacturer Sales Highest Quality GAMMA-CYCLODEXTRIN CAS 17465-86-0 For stock delivery

Send your message to this supplier


*From:	Your email address is incorrect!
*To:	Leader Biochemical Group
*Subject:	Subject is empty!
*Message:	For the best results, we recommend including the following details: -Self introduction -Required specifications -Inquire about price/MOQ Characters Remaining: (0/3000) Please enter 20 to 3000 characters to contact this supplier!

Categories	Active Biochemical Ingredients-3000MT/Year
Brand Name:	Leader
Model Number:	LD
Certification:	ISO,GMP,SGS,HALA,KOSER,HACCP
Place of Origin:	CHINA
MOQ:	25KGS
Price:	Negotiate Depend on order quantity
Payment Terms:	Western Union, MoneyGram, T/T, L/C
Supply Ability:	10MTS/Month
Delivery Time:	2-3 working days
Packaging Details:	25KG/Drum
Purity:	99.9%
Use:	Health care
Origin:	China
Package:	1KG/Tin 25KG/Drum*Carton
Manufacturer:	XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD