Recombinant Rabbit Antibody (2019-NCoV) Spike Neutralizing Antibody, Rabbit Antibody

Recombinant Rabbit antibody (2019-nCoV) Spike Neutralizing Antibody, Rabbit Antibody

Background

The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

Specification Data

Description of first aid measures

General information : No special measures required.

After inhalation :If inhaled, remove to fresh air.If not breathing give artificial respiration.Seek medical attention if needed.

After skin contact: In case of contact, wash skin with soap and copious amounts of water. Seek medical attention if needed.

After eye contact : In case of contact ,flush eyes with copious amounts of water for at least 15 minutes.Seek medical attention if needed.

After swallowing : If swallowed, wash out mouth with water provided person is conscious. Seek medical attention if needed.

Serial dilutions of Anti-SARS-CoV-2 Neutralizing Antibody (Catalog# 40592-R117) was detected by SARS-CoV-2 (2019-nCoV) Inhibitor Screening ELISA Kit. The IC50 is typically 0.5-5 nM.

The neutralization activity is Measured by microneutralization assay in vitro. The virus microneutralizaiton (MN) test was performed on 293T-ACE2 cells infected with SARS-CoV-2 (2019-nCoV) Spike Pseudovirus under treatment of serial dilutions of neutralizing antibody. The infection was neutralized by increasing concentrations of Anti-SARS-CoV-2 Neutralizing Antibody. Rate of inhibition was determined by comparing the Relative Light Unit (RLU) of Luciferase reporter in different antibody concentrations. The IC50 is typically 0.185 µg/mL.

FAQ

1. Q:Are you a factory or trading company?
A: We are a factory, we have rich experience for manufacturing Medical Device more than 10 years.
2.Q:Where is your factory located? How can i visit there?
A: Our factory is located in Jiaxing city, Zhejiang Province, China.
It is about more than 1 hours from Shanghai.

2. 3.Q:Can you make samples?
A: Yes, we can make samples for you.
4.Q:How does your factory do as quality control?
A: Quality is the lift of our factory. We have inspector in different post, and there are three inspectors before packing to get best quality products.
5.Q: How is your post market service ?
A: If any damaged rings in the course of carriage, with the checking it's our mistake, we will take full responsibility to compensate the customers.

6.Q:Can you do OEM for us?
A: Certainly. We also can build the moulding for our new customer.

7.Q:Does the price include freight?
A:No, please choose the express service provider or negotiate with us.

Established in 2009, Orient New Life Medical Co., Ltd., is specialized in high-tech biological diagnostic test development, research and production, as well as high-tech medical device development, research and production. New Life has built up two production base, which produce biological diagnostic test and endoscopic medical device respectively. Our products ranged in the following specialties: drug of abuse tests, fertility tests, infectious diseases tests, sexual transmitted diseases tests, tumor markers tests, cardiac markers tests, veterinary tests, and surgical stapler series.

NEW LIFE have 3 wholly-owned and joint stock subsidiary companies, including Orient New Life Medical  Co., Ltd., Orient Gene Biotech Co., Ltd., Qianjing Medical Equipment Co., Ltd.

Company's core technical team with more than 35 employees，3 doctors and 25 masters. They have many years of famous universities in the United States and pharmaceutical companies engaged in the project research and development, production and marketing, business management experience.Company owns hundreds of grade purification workshop and all level of quality checkout room, equipped with various production and testing equipment.