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DiscoveRx Kinase Assays

DiscoveRx Kinase Assays
Country/Region china
Company DiscoveRx co.,Ltd
Categories Chemiluminescence Detection
ICP License Issued by the Chinese Ministry
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    DiscoveRx Kinase Assays

    DiscoveRx Kinase Assays

    Kinases are a large and complex class of highly druggable target proteins that are inherent to most signaling pathways.DiscoveRx offers the broadest panel of kinase solutions for functional activity, characterization, profiling, screeningand pathway information. These generic, no-wash assays include cell-based and in-vitro assays. The cell-based kinaseportfolio provides a cellular context to the kinase activation and use full length proteins well-suited for identifying novelinhibitors and antibodies, while the in-vitro assays provide quick and easy screening approach for both active andunactive kinases.

    Product Features

    Homogeneous, non-radioactive assays
    Choice of either target specific cell-based assays or universal
    assays for purified kinase
    Broad applicability to many target classes
    Simple, one to two step protocol - saving you time during assay
    development and high throughput screening providing you convenience

    Receptor Tyrosine
    Kinase Assays
    PathHunter receptor tyrosine kinase assays are whole cell functional assay, based on theinteraction between receptor tyrosine kinases and SH2 binding domain. The assay is ideal for novel inhibitor screening,characterization and antibody therapeutics.Read more
    Targets: TrkA, TrkB, TrkC, INSR, IGFR1, FGFR4, EphB4, PDGFRb, ErbB4, ErbB3/B4, Flt-3
    Cytosolic Tyrosine
    Kinase Assays
    PathHunter protein:protein interaction system has been extended to study receptors withoutkinase domains that couple to cytosolic kinases.Read more
    Targets: JAK1, JAK2, PRLR, GHR
    Pathway Assays
    PathHunter pathway assays are novel protein-protein interaction assays for pathway analysis.These are cell-based functional assays. Read more
    Targets: IB availableRead More,FOXO3-Akt coming soon!
    Universal Assays
    ADP accumulation assays employ a generic, non-antibody based,
    non-radioactive method to detectthe amount of ADP produced during phosphorylation. This universal assay works with any kinases, ATPase or UTPase with no needfor antibody or modified substrates.Read more
    Targets: Protein Kinases, Lipid Kinases, Non-protein Kinases, ATPases, UTPases, GTPases
    EFC Assays
    HitHunter Kinase binding assays are ideal for inactive/low activity kinases. No substrate orantibody is required and hence it gives an opportunity to find novel kinase inhibitors such as ATP competitive binders andallosteric compounds.Read more
    Targets: P38 MAP Kinases, LCK, PKC, SRC, C-Kit, RTK, Serine
    Threonine Kinases
    Detection Reagents
    Chemiluminescent detection reagents for use with all PathHunter
    Cell Lines. Kits available for either Glow or Flash luminescence.
    Read More

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