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Mode of action (MOA) in vitro assays

Mode of action (MOA) in vitro assays

Country/Region China
Company IBR Inc.
Categories Other Outdoor Lighting
Update 2011-05-30 11:29:08
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IBR Inc.
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Mode of action (MOA) in vitro assays


MOA in vitro assays are used in lead selection and optimization. Data are also widely used for risk assessment analysis. The MOA of a compound may be explored in a bioassay by measuring drug binding to a cell surface receptor or other initial protein interaction. MOA bioassays may trace uptake and intracellular transport of compounds or measure interference with intracellular signaling events such as receptor phosphorylation, calcium flux or gene activation. Furthermore, readouts may also focus on metabolic effects, cell proliferation and cell death (apoptosis), not to mention detection of de novo protein synthesis and protein secretion.
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