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Light Yellow Liquid Pain Killer Diprivan / Propofol For General Anesthesia CAS 2078-54-8

Categories Local Anesthesia Drugs
Brand Name: pharmasupply
Model Number: pain killers
Certification: ISO9001, USP, BP, GMP
Place of Origin: Hubei, China
MOQ: 10g
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Supply Ability: 5000KG/week
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Name: Propofol
Appearance: Powder
Assay: 99% min.
MOQ: 10g
Grade: Pharma Grade
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    Light Yellow Liquid Pain Killer Diprivan / Propofol For General Anesthesia CAS 2078-54-8

    Light Yellow Liquid Pain Killer Diprivan / Propofol For General Anesthesia CAS 2078-54-8


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    Propofol Basic information
    Product Name:Propofol
    Synonyms:Diprivan10;Disoprofol;PD18215;Phenol, 2,6-diisopropyl-;Phenol,2,6-bis(1-methylethyl)-;Phenol,2,6-diisopropyl-;propofol(INN);2,6-DIISOPROPYLPHENOL
    CAS:2078-54-8
    MF:C12H18O
    MW:178.27
    EINECS:218-206-6
    Product Categories:Phenols;DIPRIVAN;Heterocyclic Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;GABA/Glycine receptor;GABA;Aromatics;C9 to C20+;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;DIG-DY;Organic Building Blocks;Oxygen Compounds
    Mol File:2078-54-8.mol

    Propofol Structure



    Propofol, marketed as Diprivan among other names, is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. It is also used for status epilepticus if other medications have not worked.[3] It is given by injection into a vein. Maximum effect takes about two minutes to occur and it typically lasts five to ten minutes.

    Common side effects include an irregular heart rate, low blood pressure, burning sensation at the site of injection, and the stopping of breathing.Other serious side effects may include seizures, infections with improper use, addiction, and propofol infusion syndrome with long-term use. It appears to be safe for using during pregnancy but has not been well studied in this group. However, it is not recommended during cesarean section.Propofol is not a pain medication, so opioids such as morphine may also be used.Whether or not they are always needed is unclear. Propofol is believed to work at least partly via a receptor for GABA.

    Propofol was discovered in 1977 and approved for use in the United States in 1989.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.It is available as a generic medication.The wholesale price in the developing world is between 0.61 and 8.50 USD per vial. It has been referred to as milk of amnesia (a play on milk of magnesia) because of the milk-like appearance of the intravenous preparation. Propofol is also used in veterinary medicine for anesthesia


    Medical uses

    Anesthesia

    Propofol is used for induction and maintenance (in some cases) of general anesthesia, having largely replaced sodium thiopental. It can also be administered as part of an anaesthesia maintenance technique called total intravenous anesthesia using either manually-programmed infusion pumps or computer-controlled infusion pumps in a process calledtarget controlled infusion or TCI. Propofol is also used to sedate individuals who are receiving mechanical ventilation but are not undergoing surgery, such as patients in the intensive care unit. In critically ill patients, propofol has been found to be superior to lorazepam both in effectiveness and overall cost. Propofol may be more expensive in the short term but ultimately decreases ICU stay length, thus overall lowering costs. One of the reasons Propofol is thought to be more effective (although it has a longer half life than lorazepam) is because studies have found that benzodiazepines like midazolam and lorazepam tend to accumulate in critically ill patients, prolonging sedation.

    Propofol is often used instead of sodium thiopental for starting anesthesia because recovery from propofol is more rapid and "clear."

    Propofol is very commonly used in the ICU as a sedation medication for intubated people.It can be run through aperipheral IV or central line. Propofol is commonly paired with fentanyl (for pain relief) in intubated and sedated people. Both are compatible in IV form.

    Procedural sedation

    Propofol is also used for procedural sedation. Its use in these settings results in a faster recovery compared tomidazolam.It can also be combined with opioids or benzodiazepines. Because of its fast induction and recovery time, propofol is also widely used for sedation of infants and children undergoing MRI. It is also often used in combination with ketamine as the two together have lower rates of side effects.


    Propofol Chemical Properties
    Melting point18 °C(lit.)
    Boiling point256 °C764 mm Hg(lit.)
    density0.962 g/mL at 25 °C(lit.)
    vapor pressure5.6 mm Hg ( 100 °C)
    refractive indexn20/D 1.514(lit.)
    Fp>230 °F
    storage temp.0-6°C
    solubilityVery slightly soluble in water, miscible with hexane and with methanol
    pkapKa 11.10(H2O,t =20)(Approximate)
    formneat
    Water SolubilityVery slightly soluble in water.
    Merck14,7834
    BRN1866484

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    MOQ:10g

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