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CAS 330784-47-9 Sex Steroid Hormones High Purity Avanafil 1-Dehydropiandrosterone

Categories Sex Steroid Hormones
Brand Name: Nanjian
Model Number: WH20160112
Certification: ISO9001
Place of Origin: China
MOQ: Negotiation
Price: negotiable
Payment Terms: L/C, T/T, Western Union, MoneyGram
Supply Ability: 1000kg per month
Delivery Time: 2-3working days
Packaging Details: Disguised Or Discreet
Alias: 1-Dehydropiandrosterone
Appearence: White Crystalline Powder
Molecular Formula: C23H26ClN7O3
Molecular Weight: 483.9506
Purity: 99%
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    CAS 330784-47-9 Sex Steroid Hormones High Purity Avanafil 1-Dehydropiandrosterone


    Safe 330784-47-9 Sex Steroid Hormones High Purity Avanafil 1-Dehydropiandrosterone


    Detailed Product Description
    Other nameAvanafil
    CAS330784-47-9
    Molecular FormulaC23h26cln7o3
    Molecular Weight483.9506
    Assay99% Min.
    CharacterWhite to Cyrstalline Solid

    Avanafil Description:

    Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are , tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutes.

    In addition to the active ingredient, avanafil, each tablet contains the following inactive ingredients: mannitol, fumaric acid, hydroxypropylcellulose, low substituted hydroxypropylcellulose, calcium carbonate, magnesium stearate, and ferric oxide yellow.


    Usage:


    It is a development of the phosphodiesterase type 5 inhibitors, for the treatment of male sexual dysfunction, at present in the America, EU and Japan have completed phase II clinical trials, phase III clinical trials will start. The product is composed of Japanese Tanabe Pharma Company and VIVUS company development. In addition to oral dosage forms, VIVUS company is also developing Avanafil urethral administration, for not responding to oral dosage forms of patients.

    Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular effects of avanafil should be weaker than .

    Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme phosphodiesterase 5 inhibitor induced and other.


    COA:




    Test Items

    Specification

    Test Results

    Description

    White or off-white crystalline powder

    Off-white crystalline powder

    Specific rotation

    -56°~-60°

    -58.2°

    Identification

    IR

    Matches with working standard

    Complies

    HPLC

    Solubility

    Freely soluble in chloroform and in alcohol; Very slightly soluble in water

    Conform

    Heavy metals

    ≤10ppm

    <10ppm

    Water

    ≤0.3%

    0.22%

    Residue on ignition

    ≤0.1%

    0.05%

    Relative material

    Maximum impurities≤0.5%

    0.36%

    Total impurities≤1.0%

    0.52%

    Assay

    98.5~101.0%

    99.68%

    Conclusion

    The specification conform with Enterprise standard




    Packaging & Delivery

    1). We promise to provide high purity of raw steroid powders & semi-finished liquid;

    2). We have professional packing team always find new ways to make the disguised package for custom pass guaranteed;

    3). We have Long term cooperation Express courier companies to delivery your goods safe and speedy door to door;

    4). We always thinking more for customers, 24/7 good after-sale service to solve the problems at any time;

    5). Resend policy once the parcel delivery failed by accident.


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